A placebo-controlled study of sildenafil effects on cognition in schizophrenia

BACKGROUND: Phosphodiesterase 5 (PDE5) inhibitors increase cyclic guanosine monophosphate (cGMP) concentrations in the intracellular pathway activated by N-methyl-d-aspartic acid receptors which is believed to mediate long-term potentiation and memory consolidation. The PDE5 inhibitor sildenafil has...

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Bibliographic Details
Main Authors: Goff, Donald C., Cather, Corinne, Freudenreich, Oliver, Henderson, David C., Evins, A. Eden, Culhane, Melissa A., Walsh, Jared P.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2008
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704618/
https://ncbi.nlm.nih.gov/pubmed/18716761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-008-1278-5
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