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Splenic Phagocytes Promote Responses to Nucleosomes in (NZB × NZW) F(1) Mice

Autoantigen presentation to T cells is crucial for the development of autoimmune disease. However, the mechanisms of autoantigen presentation are poorly understood. In this study, we show that splenic phagocytes play an important role in autoantigen presentation in murine lupus. Nucleosomes are majo...

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Autores principales: Okamoto, Akiko, Fujio, Keishi, van Rooijen, Nico, Tsuno, Nelson H., Takahashi, Koki, Tsurui, Hiromichi, Hirose, Sachiko, Elkon, Keith B., Yamamoto, Kazuhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704580/
https://ncbi.nlm.nih.gov/pubmed/18832681
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