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Increased ROS generation in subsets of OGG1 knockout fibroblast cells
Oxoguanine DNA glycosylase (OGG1) is a major base excision repair protein responsible for excision of the mutagenic 8-oxoguanosine (8-oxoG) lesions from the genome. Despite OGG1’s importance, the moderate phenotype of Ogg1-null (Ogg1(−/−)) mice is not well understood. This study addresses a mechanis...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704552/ https://ncbi.nlm.nih.gov/pubmed/18006041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2007.09.005 |
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