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CD59 Blockade Enhances Antigen Specific CD4(+) T Cell Responses In Humans: A New Target For Cancer Immunotherapy?

CD59, a broadly expressed GPI anchored molecule, regulates formation of the membrane attack complex of the complement cascade. We previously demonstrated that mouse CD59 also down-modulates CD4(+) T cell activity in vivo. In this study, we explored the role of CD59 on human CD4(+) T cells. Our data...

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Podrobná bibliografie
Hlavní autoři: Sivasankar, Baalasubramanian, Longhi, M Paula, Gallagher, Kathleen ME, Betts, Gareth J, Morgan, B Paul, Godkin, Andrew J, Gallimore, Awen M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704398/
https://ncbi.nlm.nih.gov/pubmed/19380765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804243
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