Kidney-targeted Birt-Hogg-Dubé gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

BACKGROUND: Germline mutations in the BHD tumor suppressor are associated with an increased risk for kidney cancer among patients with Birt-Hogg-Dubé (BHD) syndrome. BHD encodes folliculin, a novel protein that may interact with the energy- and nutrient-sensing 5′-AMP activated protein kinase-mammal...

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Autori principali: Baba, Masaya, Furihata, Mutsuo, Hong, Seung-Beom, Tessarollo, Lino, Haines, Diana C., Southon, Eileen, Patel, Vishal, Igarashi, Peter, Alvord, W. Gregory, Leighty, Robert, Yao, Masahiro, Bernardo, Marcelino, Ileva, Lilia, Choyke, Peter, Warren, Michelle B., Zbar, Berton, Linehan, W. Marston, Schmidt, Laura S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704336/
https://ncbi.nlm.nih.gov/pubmed/18182616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djm288
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