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Both cell-surface and secreted CSF-1 expressed by tumor cells metastatic to bone can contribute to osteoclast activation

Tumors metastatic to the bone produce factors that cause massive bone resorption mediated by osteoclasts in the bone microenvironment. Colony stimulating factor (CSF-1) is strictly required for the formation and survival of active osteoclasts, and is frequently produced by tumor cells. Here we hypot...

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Bibliografische gegevens
Hoofdauteurs: Yagiz, Kader, Rittling, Susan R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704245/
https://ncbi.nlm.nih.gov/pubmed/19427849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.05.002
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