Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer

BACKGROUND: Murine studies suggest that myeloid cells such as vascular leukocytes (VLC) and Tie2(+ )monocytes play a critical role in tumor angiogenesis and vasculogenesis. Myeloid cells are a primary cause of resistance to anti-VEGF therapy. The elimination of these cells from the tumor microenviro...

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Main Authors: Pulaski, Heather L, Spahlinger, Gregory, Silva, Ines A, McLean, Karen, Kueck, Angela S, Reynolds, R Kevin, Coukos, George, Conejo-Garcia, Jose R, Buckanovich, Ronald J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704183/
https://ncbi.nlm.nih.gov/pubmed/19545375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-49
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