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Uncoupling Protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose

Recent evidence suggests that mitochondrial uncoupling protein 2 (UCP2) in pancreatic β cells plays a crucial role in insulin production and secretion. We hypothesized that two UCP2 polymorphisms, a −55C/T (Ala55Val) substitution in exon 4 and an exon 8 insertion, would alter the acute insulin respo...

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Main Authors: Willig, Amanda L., Casazza, Krista R., Divers, Jasmin, Bigham, Abigail W., Gower, Barbara A., Hunter, Gary R., Fernandez, Jose R
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704067/
https://ncbi.nlm.nih.gov/pubmed/19368944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2009.02.016
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