Heat Shock Protein 27 Overexpression Mitigates Cytokine-Induced Islet Apoptosis and Streptozotocin-Induced Diabetes

β-Cell apoptosis occurs in diabetes mellitus (DM). Heat shock protein (HSP) 27 (human homolog of rodent HSP25) mitigates stress-induced apoptosis but has not been studied in β-cells. We tested whether HSP27 overexpression attenuates streptozotocin (SZ)-induced DM in vivo and cytokine-induced islet a...

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Main Authors: Dai, Tiane, Patel-Chamberlin, Mina, Natarajan, Rama, Todorov, Ivan, Ma, Jun, LaPage, Janine, Phillips, Lynetta, Nast, Cynthia C., Becerra, Diana, Chuang, Peter, Tong, Lili, de Belleroche, Jacqueline, Wells, Dominic J., Wang, Ying, Adler, Sharon G.
格式: Artigo
語言:Inglês
出版: The Endocrine Society 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703555/
https://ncbi.nlm.nih.gov/pubmed/19325007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0732
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