Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

BACKGROUND: Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics. Identification of anti-schistosomal chemicals has traditionally relied on phenotypic (whole organism) screening with adu...

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Autors principals: Abdulla, Maha-Hamadien, Ruelas, Debbie S., Wolff, Brian, Snedecor, June, Lim, Kee-Chong, Xu, Fengyun, Renslo, Adam R., Williams, Janice, McKerrow, James H., Caffrey, Conor R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702839/
https://ncbi.nlm.nih.gov/pubmed/19597541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000478
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