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Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in Caenorhabditis elegans Elongator Mutants
Elongator is a six subunit protein complex, conserved from yeast to humans. Mutations in the human Elongator homologue, hELP1, are associated with the neurological disease familial dysautonomia. However, how Elongator functions in metazoans, and how the human mutations affect neural functions is inc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2702823/ https://ncbi.nlm.nih.gov/pubmed/19593383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000561 |
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