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Hypertension of Kcnmb1(−/−) is linked to deficient K secretion and aldosteronism
Mice lacking the β1-subunit (gene, Kcnmb1; protein, BK-β1) of the large Ca-activated K channel (BK) are hypertensive. This phenotype is thought to result from diminished BK currents in vascular smooth muscle where BK-β1 is an ancillary subunit. However, the β1-subunit is also expressed in the renal...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701967/ https://ncbi.nlm.nih.gov/pubmed/19556540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904635106 |
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