Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-β(2) signaling

During human embryogenesis, neural crest cells migrate to the anterior chamber of the eye and then differentiate into the inner layers of the cornea, the iridocorneal angle, and the anterior portion of the iris. When proper development does not occur, this causes iridocorneal angle dysgenesis and in...

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Main Authors: Iwao, Keiichiro, Inatani, Masaru, Matsumoto, Yoshihiro, Ogata-Iwao, Minako, Takihara, Yuji, Irie, Fumitoshi, Yamaguchi, Yu, Okinami, Satoshi, Tanihara, Hidenobu
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701878/
https://ncbi.nlm.nih.gov/pubmed/19509472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38519
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