Proinflammatory and Th2 Cytokines Regulate the High Affinity IgE Receptor (FcεRI) and IgE-Dependant Activation of Human Airway Smooth Muscle Cells

BACKGROUND: The high affinity IgE receptor (FcεRI) is a crucial structure for IgE-mediated allergic reactions. We have previously demonstrated that human airway smooth muscle (ASM) cells express the tetrameric (αβγ2) FcεRI, and its activation leads to marked transient increases in intracellular Ca(2...

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Hauptverfasser: Redhu, Naresh Singh, Saleh, Ali, Shan, Lianyu, Gerthoffer, William T., Kung, Sam K., Halayko, Andrew J., Lamkhioued, Bouchaib, Gounni, Abdelilah S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701636/
https://ncbi.nlm.nih.gov/pubmed/19582151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006153
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