Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System

Mammalian TBP consists of a 180 amino acid core that is common to all eukaryotes, fused to a vertebrate-specific N-terminal domain. We generated mice having a modified tbp allele, tbp(ΔN), that produces a version of TBP lacking 111 of the 135 vertebrate-specific amino acids. Most tbp(ΔN/ΔN) fetuses...

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Hauptverfasser: Hobbs, Nicole K., Bondareva, Alla A., Barnett, Sheila, Capecchi, Mario R., Schmidt, Edward E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701386/
https://ncbi.nlm.nih.gov/pubmed/12150996
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