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Extrinsic Interactions Dominate Helical Propensity in Coupled Binding and Folding of Lactose Repressor Protein Hinge Helix
A significant number of eukaryotic regulatory proteins are predicted to have disordered regions. Many of these proteins bind DNA, which may serve as a template for protein folding. Similar behavior is seen in the prokaryotic LacI/GalR family of proteins that couple hinge-helix folding with DNA bindi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701349/ https://ncbi.nlm.nih.gov/pubmed/16669632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052619p |
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