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Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

Genome-wide association studies (GWAS) have successfully identified common single nucleotide polymorphisms (SNPs) associated with a wide variety of complex diseases, but do not address gene function or establish causality of disease-associated SNPs. We recently used GWAS to identify SNPs in a genomi...

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Autores principales: Woodward, Owen M., Köttgen, Anna, Coresh, Josef, Boerwinkle, Eric, Guggino, William B., Köttgen, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700910/
https://ncbi.nlm.nih.gov/pubmed/19506252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901249106
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