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The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae

The cellular response to stress conditions involves a decision between survival or cell death when damage is severe. A conserved stress response in eukaryotes involves endonucleolytic cleavage of transfer RNAs (tRNAs). The mechanism and significance of such tRNA cleavage is unknown. We show that in...

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Bibliographic Details
Main Authors: Thompson, Debrah M., Parker, Roy
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700514/
https://ncbi.nlm.nih.gov/pubmed/19332891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200811119
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