Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

BACKGROUND: Host restriction factor APOBEC3G (A3G) blocks human immunodeficiency virus type 1 (HIV-1) replication by G-to-A hypermutation, and by inhibiting DNA synthesis and provirus formation. Previous reports have suggested that A3G is a dimer and its virion incorporation is mediated through inte...

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Détails bibliographiques
Auteurs principaux: Friew, Yeshitila N, Boyko, Vitaly, Hu, Wei-Shau, Pathak, Vinay K
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700067/
https://ncbi.nlm.nih.gov/pubmed/19497112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-56
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