Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression

Bacterial lipopolysaccharide (LPS) induces monocytes/macrophages to express proinflammatory cytokines and tissue factor (TF), the primary activator of the coagulation cascade. Anti-inflammatory signaling pathways including the phosphatidylinositol-3-kinase (PI3K)-Akt pathway inhibit proinflammatory...

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Bibliographic Details
Main Authors: Baker, Alyson K., Wang, Ruipeng, Mackman, Nigel, Luyendyk, James P.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699995/
https://ncbi.nlm.nih.gov/pubmed/19447494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.04.011
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