Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians

OBJECTIVE: Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity. RESEARCH DESIGN AND METHODS: SIM1 was sequenced in 96 individuals. Variants (n =...

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Autori principali: Traurig, Michael, Mack, Janel, Hanson, Robert L., Ghoussaini, Maya, Meyre, David, Knowler, William C., Kobes, Sayuko, Froguel, Philippe, Bogardus, Clifton, Baier, Leslie J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2009
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699863/
https://ncbi.nlm.nih.gov/pubmed/19401419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0028
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