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Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
We created an inflammation-induced Parkinson’s disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor–gamma (PPAR-γ), can preven...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699576/ https://ncbi.nlm.nih.gov/pubmed/18207323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2007.12.019 |
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