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Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage
The DNA repair enzyme human uracil DNA glycosylase (UNG) scans short stretches of genomic DNA and captures rare uracil bases as they transiently emerge from the DNA duplex via spontaneous base pair breathing motions. The process of DNA scanning requires that the enzyme transiently loosen its grip on...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699497/ https://ncbi.nlm.nih.gov/pubmed/19339520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp161 |
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