Foxo3−/− mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution

B cell antigen receptor (BCR) cross-linking promotes proliferation and survival of mature B cells. Phosphoinositide-3-kinase-mediated down-regulation of pro-apoptotic and anti-mitogenic genes such as the Foxo family of transcription factors is an important component of this process. Previously, we d...

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Библиографические подробности
Главные авторы: Hinman, Rochelle M., Nichols, Whitney A., Diaz, Tracy M., Gallardo, Teresa D., Castrillon, Diego H., Satterthwaite, Anne B.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2009
Предметы:
Original Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699488/
https://ncbi.nlm.nih.gov/pubmed/19502585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp049
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