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Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates
In acute inflammation, extracellular ATP activates P2X(7) ion channel receptors (P2X(7)R) on M1 polarized macrophages to release pro-inflammatory IL-1β through activation of the caspase-1/nucleotide-binding domain and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome. In co...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699392/ https://ncbi.nlm.nih.gov/pubmed/19536133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.163 |
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