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Drug-induced liver injury: Is it somehow foreseeable?

The classic view on the pathogenesis of drug-induced liver injury is that the so-called parent compounds are made hepatotoxic by metabolism (formation of neo-substances that react abnormally), mainly by cytochromes P-450 (CYP), with further pathways, such as mitochondrial dysfunction and apoptosis,...

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Detalles Bibliográficos
Main Authors: Tarantino, Giovanni, Di Minno, Matteo Nicola Dario, Capone, Domenico
Formato: Artigo
Idioma:Inglês
Publicado: The WJG Press 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698999/
https://ncbi.nlm.nih.gov/pubmed/19533803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.15.2817
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