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Drug-induced liver injury: Is it somehow foreseeable?
The classic view on the pathogenesis of drug-induced liver injury is that the so-called parent compounds are made hepatotoxic by metabolism (formation of neo-substances that react abnormally), mainly by cytochromes P-450 (CYP), with further pathways, such as mitochondrial dysfunction and apoptosis,...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The WJG Press
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698999/ https://ncbi.nlm.nih.gov/pubmed/19533803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.15.2817 |
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