Toll-like Receptor 4 Mediates Innate Immunity to Kaposi Sarcoma Herpesvirus

The involvement of Toll-like receptor 4 (TLR4) in immunity against human herpesviruses has not been previously demonstrated. We show that infection of endothelial cells with Kaposi sarcoma herpesvirus (KSHV), a human oncogenic virus, leads to rapid suppression of TLR4 expression. This is a mechanism...

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Main Authors: Lagos, Dimitrios, Vart, Richard James, Gratrix, Fiona, Westrop, Samantha Jane, Emuss, Victoria, Wong, Ping-Pui, Robey, Rebecca, Imami, Nesrina, Bower, Mark, Gotch, Frances, Boshoff, Chris
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698447/
https://ncbi.nlm.nih.gov/pubmed/18996347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.09.012
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