Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation

Somatic mutations of the Adenomatous polyposis coli (APC) gene are initiating events in the majority of sporadic colon cancers. A common characteristic of such tumors is reduction in the number of goblet cells that produce the mucin MUC2, the principal component of intestinal mucus. Consistent with...

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Detalhes bibliográficos
Main Authors: Yang, Kan, Popova, Natalia V., Yang, WanCai, Lozonschi, Ioanna, Tadesse, Selam, Kent, Scott, Bancroft, Laura, Matise, Ilze, Cormier, Robert T., Scherer, Stefan J., Edelmann, Winfried, Lipkin, Martin, Augenlicht, Leonard, Velcich, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698434/
https://ncbi.nlm.nih.gov/pubmed/18794118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0598
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