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Tbx1 Regulates the BMP-Smad1 Pathway in a Transcription Independent Manner
Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We discovered that Tbx1 binds Smad1 and suppresses the Bmp4/Smad1 signaling. Tbx1 interferes with Smad1 to Smad4 bindin...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698216/ https://ncbi.nlm.nih.gov/pubmed/19557177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006049 |
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