Potent anti-inflammatory effects of two quinolinedione compounds, OQ1 and OQ21, mediated by dual inhibition of inducible NO synthase and cyclooxygenase-2

BACKGROUND AND PURPOSE: Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been suggested as key components in various inflammatory diseases. Here we examined the effects of new quinolinedione derivatives, 6-(4-fluorophenyl)-amino-5,8-quinolinedione (OQ1) and 6-(2,3,4-trifluoro...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Lim, Kyung-Min, Lee, Joo-Young, Lee, Song-Mi, Bae, Ok-Nam, Noh, Ji-Yoon, Kim, Eun-Jin, Chung, Seung-Min, Chung, Jin-Ho
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Publishing Ltd 2009
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697840/
https://ncbi.nlm.nih.gov/pubmed/19154436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00028.x
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