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Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin–cAMP pathway

BACKGROUND AND PURPOSE: Cyclooxygenase-2 (COX2) and hyaluronic acid (HA) are common in tumours and both independently promote tumour progression. Furthermore, COX2-dependent synthesis of prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together with HA synthesis via the...

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Detalhes bibliográficos
Main Authors: Twarock, S, Röck, K, Sarbia, M, Weber, AA, Jänicke, RU, Fischer, JW
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697807/
https://ncbi.nlm.nih.gov/pubmed/19338584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00138.x
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