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Structural features of mammalian histidine decarboxylase reveal the basis for specific inhibition

For a long time the structural and molecular features of mammalian histidine decarboxylase (EC 4.1.1.22), the enzyme that produces histamine, have evaded characterization. We overcome the experimental problems for the study of this enzyme by using a computer-based modelling and simulation approach,...

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Hlavní autoři: Moya-García, AA, Pino-Ángeles, A, Gil-Redondo, R, Morreale, A, Sánchez-Jiménez, F
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697795/
https://ncbi.nlm.nih.gov/pubmed/19413567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00219.x
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