Montelukast inhibits neutrophil pro-inflammatory activity by a cyclic AMP-dependent mechanism

BACKGROUND AND PURPOSE: The objective of this study was to characterize the effects of the cysteinyl leukotriene receptor antagonist, montelukast (0.1–2 µmol·L(−1)), on Ca(2+)-dependent pro-inflammatory activities, cytosolic Ca(2+) fluxes and intracellular cAMP in isolated human neutrophils activate...

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Autores principales: Anderson, Ronald, Theron, Annette J, Gravett, Cornelia M, Steel, Helen C, Tintinger, Gregory R, Feldman, Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2009
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697768/
https://ncbi.nlm.nih.gov/pubmed/19068077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00012.x
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