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A phase I trial using the proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for CNS malignancies
PURPOSE: To evaluate the toxicity and response rate of bortezomib with concurrent radiotherapy and temozolomide in the treatment of patients with CNS malignancies. PATIENTS AND METHODS: This open-label, dose-escalation, phase 1 clinical study evaluated the safety of 3 dose levels of intravenously ad...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697394/ https://ncbi.nlm.nih.gov/pubmed/19084346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2008.08.050 |
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