A Mitochondrial Target Sequence Polymorphism in MnSOD Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide

PURPOSE: Manganese superoxide dismutase (MnSOD) protects against oxidative damage and modulates the efficacy of chemotherapeutic drugs. A functional single nucleotide polymorphism (SNP) in codon 16 of SOD2 (rs4880), which encodes MnSOD, results in a substitution of valine by alanine (Val16Ala). We h...

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Main Authors: Glynn, Sharon A., Boersma, Brenda J., Howe, Tiffany M., Edvardsen, Hege, Geisler, Stephanie B., Goodman, Julie E., Ridnour, Lisa A., Lønning, Per E., Børresen-Dale, Anne-Lise, Naume, Bjorn, Kristensen, Vessela N, Chanock, Stephen J., Wink, David A., Ambs, Stefan
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697269/
https://ncbi.nlm.nih.gov/pubmed/19509150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0119
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