Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium

MHC-TGFcys(33) ser transgenic mice have elevated levels of active Transforming Growth Factor (TGF)-beta1 in the myocardium. Previous studies have shown that these animals develop atrial, but not ventricular, fibrosis. Here we show that atrial fibrosis was accompanied with cardiomyocyte apoptosis. Al...

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Bibliographic Details
Main Authors: Nakajima, Hidehiro, Nakajima, Hisako O., Dembowsky, Klaus, Pasumarthi, Kishore B.S., Field, Loren J.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696639/
https://ncbi.nlm.nih.gov/pubmed/16306446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000197783.70106.4a
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