A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Nitric oxide (NO(•)) competitively inhibits oxygen consumption by mitochondria at cytochrome c oxidase and S-nitrosates thiol proteins. We developed mitochondria-targeted S-nitrosothiols (MitoSNOs) that selectively modulate and protect mitochondrial function. The exemplar MitoSNO1, produced by coval...

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Detalhes bibliográficos
Main Authors: Prime, Tracy A., Blaikie, Frances H., Evans, Cameron, Nadtochiy, Sergiy M., James, Andrew M., Dahm, Christina C., Vitturi, Dario A., Patel, Rakesh P., Hiley, C. Robin, Abakumova, Irina, Requejo, Raquel, Chouchani, Edward T., Hurd, Thomas R., Garvey, John F., Taylor, Cormac T., Brookes, Paul S., Smith, Robin A. J., Murphy, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696550/
https://ncbi.nlm.nih.gov/pubmed/19528654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903250106
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