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Increased expression of Suppressor of Cytokine Signaling-1 (SOCS-1): A mechanism for dysregulated T helper-1 responses in HIV-1 Disease
Maintenance of Th1 responses and dendritic cell (DC) functions are compromised in HIV-1 infected individuals. To better understand these immune abnormalities, we developed an HIV-1 transgenic (Tg) rat. We report that Tg DCs induce elevated levels of SOCS-1 and secrete decreased IL-12p40 and elevated...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696167/ https://ncbi.nlm.nih.gov/pubmed/19135225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.11.039 |
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