Increased Sensitivity to Thermal Pain Following a Single Opiate Dose Is Influenced by the COMT val(158)met Polymorphism

Increased pain sensitivity after opioid administration (opioid-induced hyperalgesia) and/or repeated painful stimuli is an individually varying and clinically important phenomenon. The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of d...

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Bibliographic Details
Main Authors: Jensen, Karin B., Lonsdorf, Tina B., Schalling, Martin, Kosek, Eva, Ingvar, Martin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695541/
https://ncbi.nlm.nih.gov/pubmed/19547755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006016
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