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Rapid diagnosis of spinal muscular atrophy using High-Resolution Melting Analysis

BACKGROUND: Spinal muscular atrophy (SMA) is an autosomal recessive hereditary disorder caused by mutations of the survival motor neuron 1 (SMN1) gene. Recently, high-resolution DNA melting analysis (HRMA) with saturation LC Green dyes has become a powerful post-PCR technique for genotyping or mutat...

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Detalhes bibliográficos
Main Authors: Chen, Wan Jin, Dong, Wan Juan, Lin, Xiao Zhen, Lin, Min Ting, Murong, Shen Xing, Wu, Zhi Ying, Wang, Ning
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694785/
https://ncbi.nlm.nih.gov/pubmed/19480685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-10-45
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