THE PROTEASOME IS A TARGET OF OXIDATIVE DAMAGE IN HUMAN RETINA PIGMENT EPITHELIAL CELLS

PURPOSE: Dysfunction of the ubiquitin-proteasome pathway (UPP) is associated with several age-related degenerative diseases. The objective of this study is to investigate the effect of oxidative stress on the UPP in retina pigment epithelial cells. METHODS: To mimic physiological oxidative stress, A...

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Autores principales: Zhang, Xinyu, Zhou, Jilin, Fernandes, Alexandre F., Sparrow, Janet R., Pereira, Paulo, Taylor, Allen, Shang, Fu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694183/
https://ncbi.nlm.nih.gov/pubmed/18408178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-1559
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