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Hypocortisolemic clamp unmasks jointly feedforward- and feedback-dependent control of overnight ACTH secretion

BACKGROUND: ACTH secretion is under hypothalamic stimulatory (feedforward) and adrenal inhibitory (feedback) control. HYPOTHESIS: Assessment of overnight ACTH secretion during a hypocortisolemic clamp will permit the estimation of changing feedforward and feedback. SUBJECTS: Seven healthy men. INTER...

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Bibliographic Details
Main Authors: Iranmanesh, Ali, Veldhuis, Johannes D
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693721/
https://ncbi.nlm.nih.gov/pubmed/18713842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-08-0417
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