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Prion Protein Paralog Doppel Protein Interacts with Alpha-2-Macroglobulin: A Plausible Mechanism for Doppel-Mediated Neurodegeneration

Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrP(C)), together sharing common structural and biochemical properties. Unlike PrP(C), which is abundantly expressed throughout the central nervous system (CNS), Dpl protein expression is not detectable in the CNS. Interest...

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Hlavní autoři: Benvegnù, Stefano, Franciotta, Diego, Sussman, Josh, Bachi, Angela, Zardini, Elisabetta, Torreri, Paola, Govaerts, Cedric, Pizzo, Salvatore, Legname, Giuseppe
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693666/
https://ncbi.nlm.nih.gov/pubmed/19536284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005968
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