IL-12 Delivered Intratumorally by Multilamellar Liposomes Reactivates Memory T Cells in Human Tumor Microenvironments

Using a novel loading technique, IL-12 is reported here to be efficiently encapsulated within large multilamellar liposomes. The preclinical efficacy of the cytokine loaded liposomes to deliver IL-12 into human tumors and to reactive tumor-associated T cells in situ is tested using a human tumor xen...

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Bibliografiska uppgifter
Huvudupphovsmän: Simpson-Abelson, Michelle R., Purohit, Vivek S., Pang, Wing Man, Iyer, Vandana, Odunsi, Kunle, Demmy, Todd L, Yokota, Sandra J., Loyall, Jenni L., Kelleher, Raymond J., Balu-Iyer, Sathy, Bankert, Richard B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693480/
https://ncbi.nlm.nih.gov/pubmed/19395317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2009.03.516
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