T0901317, an LXR agonist, augments PKA-induced vascular cell calcification

We examined the effect of LXR agonists on vascular calcification, prevalent in atherosclerotic lesions. T0901317, an LXR agonist, augmented protein kinase A (PKA)-induced mineralization and alkaline phosphatase (ALP) activity in aortic smooth muscle cells isolated from wild-type, but not from Lxrβ(-...

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Detalhes bibliográficos
Main Authors: Hsu, Jeffrey J., Lu, Jinxiu, Huang, Michael S., Geng, Yifan, Sage, Andrew P., Bradley, Michelle N., Tontonoz, Peter, Demer, Linda L., Tintut, Yin
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692939/
https://ncbi.nlm.nih.gov/pubmed/19327357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.03.039
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