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Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1α-dependent mechanisms

Arterial O(2) levels are thought to modulate vascular smooth muscle cell (VSMC) proliferation and vascular remodeling, but the mechanisms involved are poorly understood. Here, we tested the hypothesis that PHD2, a prolyl hydroxylase domain (PHD)-containing O(2) sensor, modulates growth factor-induce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schultz, Kelly, Murthy, Vanishree, Tatro, Jeffrey B., Beasley, Debbie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692800/
https://ncbi.nlm.nih.gov/pubmed/19304911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90393.2008
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