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Diverse Chemicals Including Aryl Hydrocarbon Receptor Ligands Modulate Transcriptional Activity of the 3′Immunoglobulin Heavy Chain Regulatory Region
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a known disruptor of B-cell differentiation and a ligand for the aryl hydrocarbon receptor (AhR), induces binding of the AhR to dioxin responsive elements (DRE) in sensitive genes. The Ig heavy chain (IgH) gene is a sensitive target of TCDD and may be tran...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692577/ https://ncbi.nlm.nih.gov/pubmed/19447539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2009.03.015 |
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