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An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance

Members of the Forkhead box O (Foxo) family of transcription factors are key regulators of cellular responses, but their function in the immune system remains incompletely understood. Here we show that T cell-specific deletion of Foxo1 gene in mice led to spontaneous T cell activation, effector T ce...

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Detalhes bibliográficos
Main Authors: Ouyang, Weiming, Beckett, Omar, Flavell, Richard A., Li, Ming O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692529/
https://ncbi.nlm.nih.gov/pubmed/19285438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.02.003
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