Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

Stem cell homing and breast cancer metastasis are orchestrated by the chemokine SDF-1 and its receptor CXCR4. Here, we report the nuclear magnetic resonance (NMR) structure of a constitutively dimeric SDF-1 in complex with a CXCR4 fragment that contains three sulfotyrosine residues important for a h...

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Auteurs principaux: Veldkamp, Christopher T., Seibert, Christoph, Peterson, Francis C., De la Cruz, Norberto B., Haugner, John C., Basnet, Harihar, Sakmar, Thomas P., Volkman, Brian F.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692298/
https://ncbi.nlm.nih.gov/pubmed/18799424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.1160755
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