Plasmodium berghei ANKA: Selection of resistance to piperaquine and lumefantrine in a mouse model

We have selected piperaquine (PQ) and lumefantrine (LM) resistant Plasmodium berghei ANKA parasite lines in mice by drug pressure. Effective doses that reduce parasitaemia by 90% (ED(90)) of PQ and LM against the parent line were 3.52 and 3.93 mg/kg, respectively. After drug pressure (more than 27 p...

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Detalhes bibliográficos
Main Authors: Kiboi, D.M., Irungu, B.N., Langat, B., Wittlin, S., Brun, R., Chollet, J., Abiodun, O., Nganga, J.K., Nyambati, V.C.S., Rukunga, G.M., Bell, A., Nzila, A.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691925/
https://ncbi.nlm.nih.gov/pubmed/19318094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2009.03.010
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